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Boosting with recombinant vaccinia increases immunogenicity and protective efficacy of malaria DNA vaccine

To enhance the efficacy of DNA malaria vaccines, we evaluated the effect on protection of immunizing with various combinations of DNA, recombinant vaccinia virus, and a synthetic peptide. Immunization of BALB/c mice with a plasmid expressing Plasmodium yoelii (Py) circumsporozoite protein (CSP) indu...

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Detalhes bibliográficos
Main Authors: Sedegah, Martha, Jones, Trevor R., Kaur, Manjit, Hedstrom, Richard, Hobart, Peter, Tine, John A., Hoffman, Stephen L.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1998
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC22711/
https://ncbi.nlm.nih.gov/pubmed/9636204
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