Ligand sensitivity in dimeric associations of the serotonin 5HT2c receptor

G-protein-coupled receptors (GPCRs) respond to external stimuli by activating heterotrimeric G proteins inside the cell. There is increasing evidence that many GPCRs exist as dimers or higher oligomers, but the biochemical nature of such dimers and what roles they have, if any, in signal transductio...

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Autors principals: Mancia, Filippo, Assur, Zahra, Herman, Ariel G, Siegel, Risa, Hendrickson, Wayne A
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2008
Matèries:
Scientific Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2271072/
https://ncbi.nlm.nih.gov/pubmed/18344975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.27
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