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Production and characterization of monoclonal antibodies sensitive to conformation in the 5HT2c serotonin receptor

mAbs that are sensitive to protein conformation can be helpful in studies of protein structure and function; in particular, mAb fragments are useful reagents in membrane protein crystallization. We immunized mice with the rat 5HT2c serotonin receptor and derived clonal hybridoma cells, which we test...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Mancia, Filippo, Brenner-Morton, Susan, Siegel, Risa, Assur, Zahra, Sun, Yonghua, Schieren, Ira, Mendelsohn, Monica, Axel, Richard, Hendrickson, Wayne A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1838597/
https://ncbi.nlm.nih.gov/pubmed/17360519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700301104
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