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Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A(2 )activation

BACKGROUND: The transmissible spongiform encephalopathies (TSEs), otherwise known as the prion diseases, occur following the conversion of the normal cellular prion protein (PrP(C)) to an alternatively folded isoform (PrP(Sc)). The accumulation of PrP(Sc )within the brain leads to neurodegeneration...

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Autors principals: Bate, Clive, Tayebi, Mourad, Williams, Alun
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2270799/
https://ncbi.nlm.nih.gov/pubmed/18269734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7007-6-8
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