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Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A(2 )activation
BACKGROUND: The transmissible spongiform encephalopathies (TSEs), otherwise known as the prion diseases, occur following the conversion of the normal cellular prion protein (PrP(C)) to an alternatively folded isoform (PrP(Sc)). The accumulation of PrP(Sc )within the brain leads to neurodegeneration...
Tallennettuna:
| Päätekijät: | , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
BioMed Central
2008
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2270799/ https://ncbi.nlm.nih.gov/pubmed/18269734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7007-6-8 |
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