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Persistent inhibition of cell respiration by nitric oxide: Crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione

Both reversible and irreversible inhibition of mitochondrial respiration have been reported following the generation of nitric oxide (NO) by cells. Using J774 cells, we have studied the effect of long-term exposure to NO on different enzymes of the respiratory chain. Our results show that, although...

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Библиографические подробности
Главные авторы: Clementi, Emilio, Brown, Guy Charles, Feelisch, Martin, Moncada, Salvador
Формат: Artigo
Язык:Inglês
Опубликовано: The National Academy of Sciences 1998
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC22706/
https://ncbi.nlm.nih.gov/pubmed/9636201
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