Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose.

Nitric oxide (NO) and peroxynitrite both inhibit respiration by brain submitochondrial particles, the former reversibly at cytochrome c oxidase, the latter irreversibly at complexes I-III. Both GSH (IC50 =10 microM) and glucose (IC50 = 8 mM) prevented inhibition of respiration by peroxynitrite (ONOO...

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Bibliografische gegevens
Hoofdauteurs: Lizasoain, I, Moro, M A, Knowles, R G, Darley-Usmar, V, Moncada, S
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1996
Onderwerpen:
Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1217138/
https://ncbi.nlm.nih.gov/pubmed/8615783
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