Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose.

Nitric oxide (NO) and peroxynitrite both inhibit respiration by brain submitochondrial particles, the former reversibly at cytochrome c oxidase, the latter irreversibly at complexes I-III. Both GSH (IC50 =10 microM) and glucose (IC50 = 8 mM) prevented inhibition of respiration by peroxynitrite (ONOO...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Lizasoain, I, Moro, M A, Knowles, R G, Darley-Usmar, V, Moncada, S
פורמט: Artigo
שפה:Inglês
יצא לאור: 1996
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1217138/
https://ncbi.nlm.nih.gov/pubmed/8615783
תגים: הוספת תג
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