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Residues beyond the selectivity filter of the K(+) channel Kir2.1 regulate permeation and block by external Rb(+) and Cs(+)
1. Kir2.1 channels are blocked by Rb(+) and Cs(+) in a voltage-dependent manner, characteristic of many inward rectifier K(+) channels. Mutation of Ser165 in the transmembrane domain M2 to Leu (S165L) abolished Rb(+) blockage and lowered Cs(+) blocking affinity. At negative voltages Rb(+) carried la...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Blackwell Science Inc
2000
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2270013/ https://ncbi.nlm.nih.gov/pubmed/10896714 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.2000.00231.x |
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