pdx-1 function is specifically required in embryonic β cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis

The pdx1 gene is essential for pancreatic organogenesis in humans and mice; pdx1 mutations have been identified in human diabetic patients. Specific inactivation of pdx1 in adult β cells revealed that this gene is required for maintenance of mature β cell function. In the following study, a Cre-lox...

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Bibliographic Details
Main Authors:	Gannon, Maureen, Ables, Elizabeth Tweedie, Crawford, Laura, Lowe, David, Offield, Martin F., Magnuson, Mark A., Wright, Christopher V.E.
Format:	Artigo
Language:	Inglês
Published:	2007
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2269701/ https://ncbi.nlm.nih.gov/pubmed/18155690 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2007.10.038
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pdx-1 function is specifically required in embryonic β cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis

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