Prothrombin deficiency results in embryonic and neonatal lethality in mice

The conversion of prothrombin (FII) to the serine protease, thrombin (FIIa), is a key step in the coagulation cascade because FIIa triggers platelet activation, converts fibrinogen to fibrin, and activates regulatory pathways that both promote and ultimately suppress coagulation. However, several ob...

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Autori principali: Sun, William Y., Witte, David P., Degen, Jay L., Colbert, Melissa C., Burkart, Melissa C., Holmbäck, Kenn, Xiao, Qing, Bugge, Thomas H., Degen, Sandra J. F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 1998
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC22695/
https://ncbi.nlm.nih.gov/pubmed/9636195
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