Prothrombin deficiency results in embryonic and neonatal lethality in mice
The conversion of prothrombin (FII) to the serine protease, thrombin (FIIa), is a key step in the coagulation cascade because FIIa triggers platelet activation, converts fibrinogen to fibrin, and activates regulatory pathways that both promote and ultimately suppress coagulation. However, several ob...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22695/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9636195/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.13.7597 |
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