Prothrombin prevents fatal T cell–dependent anemia during chronic virus infection of mice

Thrombin promotes the proliferation and function of CD8+ T cells. To test if thrombin prevents exhaustion and sustains antiviral T cell activity during chronic viral infection, we depleted the thrombin-precursor prothrombin to 10% of normal levels in mice prior to infection with the clone 13 strain...

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Hlavní autoři:	Rachel Cantrell, H. Alex Feldman, Leah Rosenfeldt, Ayad Ali, Benjamin Gourley, Cassandra Sprague, Daniel Leino, Jeff Crosby, Alexey Revenko, Brett Monia, Stephen N. Waggoner, Joseph S. Palumbo
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Clinical investigation 2025-02-01
Edice:	JCI Insight
Témata:	Hematology Immunology
On-line přístup:	https://doi.org/10.1172/jci.insight.181063
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