Prothrombin prevents fatal T cell–dependent anemia during chronic virus infection of mice
Thrombin promotes the proliferation and function of CD8+ T cells. To test if thrombin prevents exhaustion and sustains antiviral T cell activity during chronic viral infection, we depleted the thrombin-precursor prothrombin to 10% of normal levels in mice prior to infection with the clone 13 strain...
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| Principais autores: | , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Clinical investigation
2025-02-01
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| Serier: | JCI Insight |
| Fag: | |
| Online adgang: | https://doi.org/10.1172/jci.insight.181063 |
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