Prothrombin deficiency results in embryonic and neonatal lethality in mice

The conversion of prothrombin (FII) to the serine protease, thrombin (FIIa), is a key step in the coagulation cascade because FIIa triggers platelet activation, converts fibrinogen to fibrin, and activates regulatory pathways that both promote and ultimately suppress coagulation. However, several ob...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Sun, William Y., Witte, David P., Degen, Jay L., Colbert, Melissa C., Burkart, Melissa C., Holmbäck, Kenn, Xiao, Qing, Bugge, Thomas H., Degen, Sandra J. F.
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1998
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22695/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9636195/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.13.7597
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