Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors

BACKGROUND: HIV-1 R5 viruses cause most of the AIDS cases worldwide and are preferentially transmitted compared to CXCR4-using viruses. Furthermore, R5 viruses vary extensively in capacity to infect macrophages and highly macrophage-tropic variants are frequently identified in the brains of patients...

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Detalhes bibliográficos
Main Authors: Peters, Paul J, Duenas-Decamp, Maria J, Sullivan, W Matthew, Brown, Richard, Ankghuambom, Chiambah, Luzuriaga, Katherine, Robinson, James, Burton, Dennis R, Bell, Jeanne, Simmonds, Peter, Ball, Jonathan, Clapham, Paul R
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268948/
https://ncbi.nlm.nih.gov/pubmed/18205925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-5-5
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