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Unmodified self antigen triggers human CD8 T cells with stronger tumor reactivity than altered antigen
Human cancer vaccines are often prepared with altered “analog” or “heteroclitic” antigens that have been optimized for HLA class I binding, resulting in enhanced immunogenicity. Here, we take advantage of CpG oligodeoxynucleotides as powerful vaccine adjuvants and demonstrate the induction of high T...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2268830/ https://ncbi.nlm.nih.gov/pubmed/18319339 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800080105 |
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