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Enhanced Bone Regeneration Associated With Decreased Apoptosis in Mice With Partial HIF-1α Deficiency
HIF-1α activates genes under hypoxia and was hypothesized to regulate bone regeneration. Surprisingly, HIF-1α(+/−) fracture calluses are larger, stronger, and stiffer than HIF-1α(+/+) calluses because of decreased apoptosis. These data identify apoptosis inhibition as a means to enhance bone regener...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2007
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2268762/ https://ncbi.nlm.nih.gov/pubmed/17181398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1359/JBMR.061207 |
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