Heterozygous HIF-1α deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia

Chronic intermittent hypoxia (CIH) occurs in patients with sleep apnoea and has adverse effects on multiple physiological functions. Previous studies have shown that reflexes arising from carotid bodies mediate CIH-evoked cardio-respiratory responses, and reactive oxygen species (ROS) play important...

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Detalhes bibliográficos
Main Authors: Peng, Ying-Jie, Yuan, Guoxiang, Ramakrishnan, Deviprasadh, Sharma, Suresh D, Bosch-Marce, Marta, Kumar, Ganesh K, Semenza, Gregg L, Prabhakar, Nanduri R
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2006
Assuntos:
Integrative
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1890436/
https://ncbi.nlm.nih.gov/pubmed/16973705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.114033
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