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Enhanced Bone Regeneration Associated With Decreased Apoptosis in Mice With Partial HIF-1α Deficiency

HIF-1α activates genes under hypoxia and was hypothesized to regulate bone regeneration. Surprisingly, HIF-1α(+/−) fracture calluses are larger, stronger, and stiffer than HIF-1α(+/+) calluses because of decreased apoptosis. These data identify apoptosis inhibition as a means to enhance bone regener...

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Detalhes bibliográficos
Main Authors: Komatsu, David E, Bosch-Marce, Marta, Semenza, Gregg L, Hadjiargyrou, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268762/
https://ncbi.nlm.nih.gov/pubmed/17181398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1359/JBMR.061207
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