Phosphatidylinositol 3-kinase signaling in proliferating cells maintains an anti-apoptotic transcriptional program mediated by inhibition of FOXO and non-canonical activation of NFκB transcription factors

BACKGROUND: Phosphatidylinositol (PI) 3-kinase is activated by a variety of growth factor receptors and the PI 3-kinase/Akt signaling pathway is a key regulator of cell proliferation and survival. The downstream targets of PI 3-kinase/Akt signaling include direct regulators of cell cycle progression...

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Detalhes bibliográficos
Main Authors: Terragni, Jolyon, Graham, Julie R, Adams, Kenneth W, Schaffer, Michael E, Tullai, John W, Cooper, Geoffrey M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268685/
https://ncbi.nlm.nih.gov/pubmed/18226221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-9-6
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