CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity

There are many inhibitory mechanisms that function at the cellular and molecular levels to maintain tolerance. Despite this, self-reactive clones escape regulatory mechanisms and cause autoimmunity in certain circumstances. We hypothesized that the same mechanisms that permit T cells to expand durin...

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Detalhes bibliográficos
Main Authors: Calzascia, Thomas, Pellegrini, Marc, Lin, Albert, Garza, Kristine M., Elford, Alisha R., Shahinian, Arda, Ohashi, Pamela S., Mak, Tak W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268574/
https://ncbi.nlm.nih.gov/pubmed/18287017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712135105
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