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Selective Ablation of Virion Host Shutoff Protein RNase Activity Attenuates Herpes Simplex Virus 2 in Mice

The virion host shutoff (vhs) protein of herpes simplex virus (HSV) has endoribonuclease activity and rapidly reduces protein synthesis in infected cells through mRNA degradation. Herpes simplex virus 1 (HSV-1) and HSV-2 vhs mutants are highly attenuated in vivo, but replication and virulence are la...

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Main Authors: Korom, Maria, Wylie, Kristine M., Morrison, Lynda A.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology (ASM) 2008
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268463/
https://ncbi.nlm.nih.gov/pubmed/18234805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02409-07
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