Structural Basis for Potent Cross-Neutralizing Human Monoclonal Antibody Protection against Lethal Human and Zoonotic Severe Acute Respiratory Syndrome Coronavirus Challenge

Severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2002, and detailed phylogenetic and epidemiological analyses have suggested that it originated from animals. The spike (S) glycoprotein has been identified as a major component of protective immunity, and 23 different amino acid cha...

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Detalhes bibliográficos
Main Authors: Rockx, Barry, Corti, Davide, Donaldson, Eric, Sheahan, Timothy, Stadler, Konrad, Lanzavecchia, Antonio, Baric, Ralph
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268459/
https://ncbi.nlm.nih.gov/pubmed/18199635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02377-07
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