Synthetic Reconstruction of Zoonotic and Early Human Severe Acute Respiratory Syndrome Coronavirus Isolates That Produce Fatal Disease in Aged Mice

The severe acute respiratory syndrome (SARS) epidemic was characterized by high mortality rates in the elderly. The molecular mechanisms that govern enhanced susceptibility of elderly populations are not known, and robust animal models are needed that recapitulate the increased pathogenic phenotype...

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Detalhes bibliográficos
Main Authors: Rockx, Barry, Sheahan, Timothy, Donaldson, Eric, Harkema, Jack, Sims, Amy, Heise, Mark, Pickles, Raymond, Cameron, Mark, Kelvin, David, Baric, Ralph
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1933338/
https://ncbi.nlm.nih.gov/pubmed/17507479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00505-07
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