Synthetic Reconstruction of Zoonotic and Early Human Severe Acute Respiratory Syndrome Coronavirus Isolates That Produce Fatal Disease in Aged Mice

The severe acute respiratory syndrome (SARS) epidemic was characterized by high mortality rates in the elderly. The molecular mechanisms that govern enhanced susceptibility of elderly populations are not known, and robust animal models are needed that recapitulate the increased pathogenic phenotype...

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Bibliographic Details
Main Authors: Rockx, Barry, Sheahan, Timothy, Donaldson, Eric, Harkema, Jack, Sims, Amy, Heise, Mark, Pickles, Raymond, Cameron, Mark, Kelvin, David, Baric, Ralph
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2007
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1933338/
https://ncbi.nlm.nih.gov/pubmed/17507479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00505-07
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