Synthetic Reconstruction of Zoonotic and Early Human Severe Acute Respiratory Syndrome Coronavirus Isolates That Produce Fatal Disease in Aged Mice

The severe acute respiratory syndrome (SARS) epidemic was characterized by high mortality rates in the elderly. The molecular mechanisms that govern enhanced susceptibility of elderly populations are not known, and robust animal models are needed that recapitulate the increased pathogenic phenotype...

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Hlavní autoři: Rockx, Barry, Sheahan, Timothy, Donaldson, Eric, Harkema, Jack, Sims, Amy, Heise, Mark, Pickles, Raymond, Cameron, Mark, Kelvin, David, Baric, Ralph
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2007
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1933338/
https://ncbi.nlm.nih.gov/pubmed/17507479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00505-07
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