Expanded CTG repeats within the DMPK 3′ UTR causes severe skeletal muscle wasting in an inducible mouse model for myotonic dystrophy

Severe skeletal muscle wasting is the most debilitating symptom experienced by individuals with myotonic dystrophy type 1 (DM1). We present a DM1 mouse model with inducible and skeletal muscle-specific expression of large tracts of CTG repeats in the context of DMPK exon 15. These mice recapitulate...

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Hlavní autoři: Orengo, James P., Chambon, Pierre, Metzger, Daniel, Mosier, Dennis R., Snipes, G. Jackson, Cooper, Thomas A.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268190/
https://ncbi.nlm.nih.gov/pubmed/18272483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708519105
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