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The DMPK gene of severely affected myotonic dystrophy patients is hypermethylated proximal to the largely expanded CTG repeat.

Using methylation-sensitive restriction enzymes, we characterized the methylation pattern on the 5' side of the CTG repeat in the DMPK gene of normal individuals and of patients affected with myotonic dystrophy, showing expansions of the repetitive sequence. The gene segment analyzed correspond...

詳細記述

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書誌詳細
主要な著者: Steinbach, P, Gläser, D, Vogel, W, Wolf, M, Schwemmle, S
フォーマット: Artigo
言語:Inglês
出版事項: 1998
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1376887/
https://ncbi.nlm.nih.gov/pubmed/9463318
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