The DMPK gene of severely affected myotonic dystrophy patients is hypermethylated proximal to the largely expanded CTG repeat.

Using methylation-sensitive restriction enzymes, we characterized the methylation pattern on the 5' side of the CTG repeat in the DMPK gene of normal individuals and of patients affected with myotonic dystrophy, showing expansions of the repetitive sequence. The gene segment analyzed correspond...

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Bibliographic Details
Main Authors: Steinbach, P, Gläser, D, Vogel, W, Wolf, M, Schwemmle, S
Format: Artigo
Language:Inglês
Published: 1998
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1376887/
https://ncbi.nlm.nih.gov/pubmed/9463318
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