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Dissection of the insulin signaling pathway via quantitative phosphoproteomics

The insulin signaling pathway is of pivotal importance in metabolic diseases, such as diabetes, and in cellular processes, such as aging. Insulin activates a tyrosine phosphorylation cascade that branches to create a complex network affecting multiple biological processes. To understand the full spe...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Krüger, Marcus, Kratchmarova, Irina, Blagoev, Blagoy, Tseng, Yu-Hua, Kahn, C. Ronald, Mann, Matthias
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268157/
https://ncbi.nlm.nih.gov/pubmed/18268350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711713105
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