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Global Effects of Kinase Inhibitors on Signaling Networks Revealed by Quantitative Phosphoproteomics
Aberrant signaling causes many diseases, and manipulating signaling pathways with kinase inhibitors has emerged as a promising area of drug research. Most kinase inhibitors target the conserved ATP-binding pocket; therefore specificity is a major concern. Proteomics has previously been used to ident...
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| Główni autorzy: | , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
The American Society for Biochemistry and Molecular Biology
2009
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2816010/ https://ncbi.nlm.nih.gov/pubmed/19651622 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M900285-MCP200 |
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