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Global Effects of Kinase Inhibitors on Signaling Networks Revealed by Quantitative Phosphoproteomics

Aberrant signaling causes many diseases, and manipulating signaling pathways with kinase inhibitors has emerged as a promising area of drug research. Most kinase inhibitors target the conserved ATP-binding pocket; therefore specificity is a major concern. Proteomics has previously been used to ident...

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Bibliografski detalji
Glavni autori: Pan, Cuiping, Olsen, Jesper V., Daub, Henrik, Mann, Matthias
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Biochemistry and Molecular Biology 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2816010/
https://ncbi.nlm.nih.gov/pubmed/19651622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M900285-MCP200
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