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Maximized quantitative phosphoproteomics allows high confidence dissection of the DNA damage signaling network

The maintenance of genomic stability relies on DNA damage sensor kinases that detect DNA lesions and phosphorylate an extensive network of substrates. The Mec1/ATR kinase is one of the primary sensor kinases responsible for orchestrating DNA damage responses. Despite the importance of Mec1/ATR, the...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Faca, Vitor Marcel, Sanford, Ethan J., Tieu, Jennifer, Comstock, William, Gupta, Shagun, Marshall, Shannon, Yu, Haiyuan, Smolka, Marcus B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7582137/
https://ncbi.nlm.nih.gov/pubmed/33093574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-74939-4
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