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An experimental survey of the transition between two-state and downhill protein folding scenarios

A kinetic and thermodynamic survey of 35 WW domain sequences is used in combination with a model to discern the energetic requirements for the transition from two-state folding to downhill folding. The sequences used exhibit a 600-fold range of folding rates at the temperature of maximum folding rat...

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Detalhes bibliográficos
Main Authors: Liu, Feng, Du, Deguo, Fuller, Amelia A., Davoren, Jennifer E., Wipf, Peter, Kelly, Jeffery W., Gruebele, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268143/
https://ncbi.nlm.nih.gov/pubmed/18268349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711908105
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