Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction

Caloric restriction (CR) is the most potent intervention known to both protect against carcinogenesis and extend lifespan in laboratory animals. A variety of anticarcinogens and CR mimetics induce and activate the NF-E2-related factor 2 (Nrf2) pathway. Nrf2, in turn, induces a number of antioxidativ...

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Autori principali: Pearson, Kevin J., Lewis, Kaitlyn N., Price, Nathan L., Chang, Joy W., Perez, Evelyn, Cascajo, Maria Victoria, Tamashiro, Kellie L., Poosala, Suresh, Csiszar, Anna, Ungvari, Zoltan, Kensler, Thomas W., Yamamoto, Masayuki, Egan, Josephine M., Longo, Dan L., Ingram, Donald K., Navas, Placido, de Cabo, Rafael
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2008
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268135/
https://ncbi.nlm.nih.gov/pubmed/18287083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712162105
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