Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction

Caloric restriction (CR) is the most potent intervention known to both protect against carcinogenesis and extend lifespan in laboratory animals. A variety of anticarcinogens and CR mimetics induce and activate the NF-E2-related factor 2 (Nrf2) pathway. Nrf2, in turn, induces a number of antioxidativ...

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書誌詳細
主要な著者: Pearson, Kevin J., Lewis, Kaitlyn N., Price, Nathan L., Chang, Joy W., Perez, Evelyn, Cascajo, Maria Victoria, Tamashiro, Kellie L., Poosala, Suresh, Csiszar, Anna, Ungvari, Zoltan, Kensler, Thomas W., Yamamoto, Masayuki, Egan, Josephine M., Longo, Dan L., Ingram, Donald K., Navas, Placido, de Cabo, Rafael
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2008
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268135/
https://ncbi.nlm.nih.gov/pubmed/18287083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712162105
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