Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction

Caloric restriction (CR) is the most potent intervention known to both protect against carcinogenesis and extend lifespan in laboratory animals. A variety of anticarcinogens and CR mimetics induce and activate the NF-E2-related factor 2 (Nrf2) pathway. Nrf2, in turn, induces a number of antioxidativ...

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Detalhes bibliográficos
Main Authors: Pearson, Kevin J., Lewis, Kaitlyn N., Price, Nathan L., Chang, Joy W., Perez, Evelyn, Cascajo, Maria Victoria, Tamashiro, Kellie L., Poosala, Suresh, Csiszar, Anna, Ungvari, Zoltan, Kensler, Thomas W., Yamamoto, Masayuki, Egan, Josephine M., Longo, Dan L., Ingram, Donald K., Navas, Placido, de Cabo, Rafael
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268135/
https://ncbi.nlm.nih.gov/pubmed/18287083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712162105
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