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Bcl-2 overexpression in PhIP-induced colon tumors: cloning of the rat Bcl-2 promoter and characterization of a pathway involving β-catenin, c-Myc and E2F1

β-Catenin/T-cell factor (Tcf) signaling is constitutively active in the majority of human colorectal cancers, and there are accompanying changes in Bcl-2 expression. Similarly, 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP)-induced colon tumors in the rat have increased β-catenin and elevate...

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Bibliografiske detaljer
Main Authors: Li, Q, Dashwood, WM, Zhong, X, Nakagama, H, Dashwood, RH
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267879/
https://ncbi.nlm.nih.gov/pubmed/17404573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.onc.1210438
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