Performance of AAV8 vectors expressing human factor IX from a hepatic-selective promoter following intravenous injection into rats

BACKGROUND: Vectors based on adeno-associated virus-8 (AAV8) have shown efficiency and efficacy for liver-directed gene therapy protocols following intravascular injection, particularly in relation to haemophilia gene therapy. AAV8 has also been proposed for gene therapy targeted at skeletal and car...

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Détails bibliographiques
Auteurs principaux: Graham, Tracey, McIntosh, Jenny, Work, Lorraine M, Nathwani, Amit, Baker, Andrew H
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2008
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267784/
https://ncbi.nlm.nih.gov/pubmed/18312698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-0556-6-9
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