Oxidative stress regulates IGF1R expression in vascular smooth-muscle cells via p53 and HDAC recruitment

Apoptosis of VSMCs (vascular smooth-muscle cells) leads to features of atherosclerotic plaque instability. We have demonstrated previously that plaque-derived VSMCs have reduced IGF1 (insulin-like growth factor 1) signalling, resulting from a decrease in the expression of IGF1R (IGF1 receptor) compa...

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Detalhes bibliográficos
Main Authors: Kavurma, Mary M., Figg, Nichola, Bennett, Martin R., Mercer, John, Khachigian, Levon M., Littlewood, Trevor D.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267398/
https://ncbi.nlm.nih.gov/pubmed/17600529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20070380
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