Interferon-γ Induces Fas Trafficking and Sensitization to Apoptosis in Vascular Smooth Muscle Cells via a PI3K- and Akt-Dependent Mechanism

Vascular smooth muscle cell (VSMC) apoptosis occurs in advanced atherosclerotic plaques where it may contribute to plaque instability. VSMCs express the death receptor Fas but are relatively resistant to Fas-induced apoptosis due in part to the intracellular sequestration of Fas. Although inflammato...

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Detalhes bibliográficos
Main Authors: Rosner, Dalya, Stoneman, Victoria, Littlewood, Trevor, McCarthy, Nicola, Figg, Nichola, Wang, Yinong, Tellides, George, Bennett, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2006
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1606618/
https://ncbi.nlm.nih.gov/pubmed/16723718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.050473
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