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A quantitative method to assess extrasynaptic NMDA receptor function in the protective effect of synaptic activity against neurotoxicity

BACKGROUND: Extrasynaptic NMDA receptors couple to a CREB shut-off pathway and cause cell death, whereas synaptic NMDA receptors and nuclear calcium signaling promote CREB-mediated transcription and neuronal survival. The distribution of NMDA receptors (synaptic versus extrasynaptic) may be an impor...

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Main Authors: Bengtson, C Peter, Dick, Oliver, Bading, Hilmar
格式: Artigo
語言:Inglês
出版: BioMed Central 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267199/
https://ncbi.nlm.nih.gov/pubmed/18218077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-9-11
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