Extending Bell's Model: How Force Transducer Stiffness Alters Measured Unbinding Forces and Kinetics of Molecular Complexes

Forced unbinding of complementary macromolecules such as ligand-receptor complexes can reveal energetic and kinetic details governing physiological processes ranging from cellular adhesion to drug metabolism. Although molecular-level experiments have enabled sampling of individual ligand-receptor co...

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Bibliographic Details
Main Authors: Walton, Emily B., Lee, Sunyoung, Van Vliet, Krystyn J.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2008
Subjects:
Biophysical Theory and Modeling
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267154/
https://ncbi.nlm.nih.gov/pubmed/18178658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.114454
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