Loading...

Molecular dynamics force probe simulations of antibody/antigen unbinding: entropic control and nonadditivity of unbinding forces.

Unbinding of a spin-labeled dinitrophenyl (DNP) hapten from the monoclonal antibody AN02 F(ab) fragment has been studied by force probe molecular dynamics (FPMD) simulations. In our nanosecond simulations, unbinding was enforced by pulling the hapten molecule out of the binding pocket. Detailed insp...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Heymann, B, Grubmüller, H
Format: Artigo
Sprog:Inglês
Udgivet: 2001
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1301611/
https://ncbi.nlm.nih.gov/pubmed/11509346
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!