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Mutations Affecting the Oligomerization Interface of G-Protein-Coupled Receptors Revealed by a Novel De Novo Protein Design Framework

Specific functional and pharmacological properties have recently been ascribed to G-protein-coupled receptor (GPCR) dimers/oligomers. Because the association of two identical or two distinct GPCR monomers seems to be required to elicit receptor function, it is necessary to understand the exact natur...

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Autori principali: Taylor, Martin S., Fung, Ho K., Rajgaria, Rohit, Filizola, Marta, Weinstein, Harel, Floudas, Christodoulos A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267121/
https://ncbi.nlm.nih.gov/pubmed/18178645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.117622
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