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Sedimentation Studies on Human Amylin Fail to Detect Low-Molecular-Weight Oligomers
Sedimentation velocity experiments show that only monomers coexist with amyloid fibrils of human islet amyloid-polypeptide. No oligomers containing <100 monomers could be detected, suggesting that the putative toxic oligomers are much larger than those found for the Alzheimer's peptide, Aβ(1...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Biophysical Society
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2267115/ https://ncbi.nlm.nih.gov/pubmed/18223003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.125146 |
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