Memantine Rescues Transient Cognitive Impairment Caused by High-Molecular-Weight Aβ Oligomers But Not the Persistent Impairment Induced by Low-Molecular-Weight Oligomers

Brain accumulation of soluble amyloid-β oligomers (AβOs) has been implicated in synapse failure and cognitive impairment in Alzheimer's disease (AD). However, whether and how oligomers of different sizes induce synapse dysfunction is a matter of controversy. Here, we report that low-molecular-w...

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Pubblicato in:J Neurosci
Autori principali: Figueiredo, Cláudia P., Clarke, Julia R., Ledo, José Henrique, Ribeiro, Felipe C., Costa, Carine V., Melo, Helen M., Mota-Sales, Axa P., Saraiva, Leonardo M., Klein, William L., Sebollela, Adriano, De Felice, Fernanda G., Ferreira, Sergio T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2013
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6619709/
https://ncbi.nlm.nih.gov/pubmed/23739959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0482-13.2013
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