Hexokinase II Detachment from Mitochondria Triggers Apoptosis through the Permeability Transition Pore Independent of Voltage-Dependent Anion Channels

Type II hexokinase is overexpressed in most neoplastic cells, and it mainly localizes on the outer mitochondrial membrane. Hexokinase II dissociation from mitochondria triggers apoptosis. The prevailing model postulates that hexokinase II release from its mitochondrial interactor, the voltage-depend...

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Bibliografiske detaljer
Main Authors: Chiara, Federica, Castellaro, Diego, Marin, Oriano, Petronilli, Valeria, Brusilow, William S., Juhaszova, Magdalena, Sollott, Steven J., Forte, Michael, Bernardi, Paolo, Rasola, Andrea
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267038/
https://ncbi.nlm.nih.gov/pubmed/18350175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001852
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