Dynamics of Co-Transcriptional Pre-mRNA Folding Influences the Induction of Dystrophin Exon Skipping by Antisense Oligonucleotides

Antisense oligonucleotides (AONs) mediated exon skipping offers potential therapy for Duchenne muscular dystrophy. However, the identification of effective AON target sites remains unsatisfactory for lack of a precise method to predict their binding accessibility. This study demonstrates the importa...

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Detalhes bibliográficos
Main Authors: Wee, Keng Boon, Pramono, Zacharias Aloysius Dwi, Wang, Jian Li, MacDorman, Karl F., Lai, Poh San, Yee, Woon Chee
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267000/
https://ncbi.nlm.nih.gov/pubmed/18365002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001844
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