Dynamics of Co-Transcriptional Pre-mRNA Folding Influences the Induction of Dystrophin Exon Skipping by Antisense Oligonucleotides

Antisense oligonucleotides (AONs) mediated exon skipping offers potential therapy for Duchenne muscular dystrophy. However, the identification of effective AON target sites remains unsatisfactory for lack of a precise method to predict their binding accessibility. This study demonstrates the importa...

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Autors principals: Wee, Keng Boon, Pramono, Zacharias Aloysius Dwi, Wang, Jian Li, MacDorman, Karl F., Lai, Poh San, Yee, Woon Chee
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2008
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267000/
https://ncbi.nlm.nih.gov/pubmed/18365002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001844
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