Dynamics of Co-Transcriptional Pre-mRNA Folding Influences the Induction of Dystrophin Exon Skipping by Antisense Oligonucleotides

Antisense oligonucleotides (AONs) mediated exon skipping offers potential therapy for Duchenne muscular dystrophy. However, the identification of effective AON target sites remains unsatisfactory for lack of a precise method to predict their binding accessibility. This study demonstrates the importa...

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Bibliografische gegevens
Hoofdauteurs: Wee, Keng Boon, Pramono, Zacharias Aloysius Dwi, Wang, Jian Li, MacDorman, Karl F., Lai, Poh San, Yee, Woon Chee
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2008
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267000/
https://ncbi.nlm.nih.gov/pubmed/18365002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001844
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