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BMP-6 exerts its osteoinductive effect through activation of IGF-I and EGF pathways

We have recently shown that human recombinant BMP-6 (rhBMP-6), given systematically, can restore bone in animal models of osteoporosis. To further elucidate the underlying mechanisms of new bone formation following systemic application of BMPs, we conducted gene expression profiling experiments usin...

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Autors principals: Grasser, W. A., Orlic, I., Borovecki, F., Riccardi, K. A., Simic, P., Vukicevic, S., Paralkar, V. M.
Format: Artigo
Idioma:Inglês
Publicat: Springer-Verlag 2007
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2266664/
https://ncbi.nlm.nih.gov/pubmed/17634942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00264-007-0407-9
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