A Ca(V)β SH3/Guanylate Kinase Domain Interaction Regulates Multiple Properties of Voltage-gated Ca(2+) Channels

Auxiliary Ca(2+) channel β subunits (Ca(V)β) regulate cellular Ca(2+) signaling by trafficking pore-forming α(1) subunits to the membrane and normalizing channel gating. These effects are mediated through a characteristic src homology 3/guanylate kinase (SH3–GK) structural module, a design feature s...

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Autores principales: Takahashi, Shoji X., Miriyala, Jayalakshmi, Tay, Lai Hock, Yue, David T., Colecraft, Henry M.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2005
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2266626/
https://ncbi.nlm.nih.gov/pubmed/16186563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200509354
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